Nimesulid can cause (besides nausea, discomfort, bleeding, damage of hepatic and renal functions), some allergic reactions including oedema (although it’s very rare). The oedema could be also caused by damaged renal function. The type of side effect depends on individual reactivity and dose od the drug. Your problems could be produced also by many other causes. Visit Your doctor to investigate the cause more exactly.
Pavel Kostiuk, M.D.